Study - No Correlation between IL-10 Polymorphisms and Peptic Ulcers

A member of the American College of Surgeons, Dr. Dan Avradopoulos is a lead physician in wound care at Heywood Hospital in Gardner, Massachusetts. An avid researcher, Dr. Dan Avradopoulos’ work was referenced in a 2014 study by the medical faculty of Hormozgan University of Medical Sciences in Bandar Abbas, Iran. The study sought to explore the frequency of interleukin-10 (IL-10) polymorphisms in patients with peptic ulcers and chronic gastritis. 

Peptic ulcer is a significant medical problem that seriously affects patients’ quality of life. One of the causes of peptic ulcers is Helicobacter pylori infection, which is related to the inflammatory responses of gastric mucosa. Anti-inflammatory cytokines such as IL-10 limit inflammatory responses. The study by Hormozgan University faculty sought to clinically establish the role of IL-10 in cases of inflammation as well as its relationship with peptic ulcers. 

For the study, 107 people with symptoms of stomach pain and indigestion, all with an indication for endoscopy, were selected as a patient group, while 107 healthy people were selected as a control group. The role of IL-10 in both groups was then examined. Researchers found no significant difference between both groups in terms of the C allele in IL-10, indicating no correlation between IL-10 polymorphisms and peptic ulcers.